The crash happened just before 5 p.m. between two SUVs at West Marquette Road and South Lafayette Avenue.
Officials have not commented on what caused or led up to the crash.
About 4:30 p.m., a woman was driving a hatchback west in the 100 block of West Marquette Road when she tried to turn left onto South Lafayette Avenue but was struck by a man driving an SUV east on Marquette Road, Chicago police said.
The woman's car then hit a traffic light pole, police said.
Three boys in her car - ages 6, 9 and 13 - were taken to Comer Children's Hospital, where they were listed in good condition, according to police.
A woman, 37, was transported in fair condition to University of Chicago Medical Center, Chicago fire officials said.
No further details have been released.
The Sun-Times Media Wire contributed to this report.