A sedan with four female passengers was speeding when it ran a red light and hit a semi-truck at about 2:28 a.m. in the 7900-block of South Pulaski Road, police said.
The Chicago Fire Department said three women were transported to Advocate Christ Hospital in critical condition and a fourth woman was transported to Mt. Sinai Medical Center in stable condition. The man driving the semi-truck declined medical treatment.
Area One detectives are investigating the crash.