Police said the bus was traveling westbound in the 1600-block of East 87th Street at about 9:25 p.m. when it was struck in the left side by a Chevrolet Malibu.
The 41-year-old driver of the Chevy was transported to the University of Chicago Medical Center in fair condition, police said.
The 28-year-old man driving the bus and a 34-year-old bus passenger were both transported to Trinity Hospital in good condition.
No other injuries were reported and police said citations are pending.