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Fans are excited for the year to come and the teams are starting with a clean slate!
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The Cubs kicked off their season with a win against the Milwaukee Brewers 4-0. The White Sox also take on the Astros at 6 p.m. in Houston.
"To be in the city and have a winning victory fir opening day is just, like, it's amazing. It was a great day," said Cubs fan, Michelle Winters.
It was a chilly forecast for Cubs fans, with a cloudy breeze and temperatures in the low to mid-40s throughout the game.
Fans at Wrigley, like Mary DeLucca and her son, are making Opening Day a family tradition.
"We've been coming to every Opening Day since 2010 as a mom-son event," DeLucca said. "This time my husband and daughter, who are Brewers fans, decided to join us."
This season, fans can expect 50 different game-day promotions, including commemorative jerseys, hats, pins and bobbleheads featuring Cubs legends.
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And don't forget the food! From burgers to loaded Greek fries, some Cubs fans from South Dakota are making room.
"Half the reason I walk around and get so many steps during vacation is just so I can eat more," Cubs fan Sam Naasz said.
Draft Kings Sportsbook, which is Wrigley's new major attraction, is set to open around mid-June.
The sports bar and wagering facility on Addison and Sheffield is set to become the largest retail sportsbook in the country connected to a professional sports venue year-round.
Cubs become 1st MLB team committing to open stadium sportsbook at Wrigley Field
"So basically, it will operate like a restaurant," Julian Green, Cubs senior VP of Communications. "It will be open seven days a week. Certainly, the hours of operation will be determined. We're still working with the Illinois Gaming Board, obviously, to get approval and what have you but we're excited to add this new amenity to the ballpark as well as to the area."
Meanwhile, fans will notice the game itself will be quicker: a pitch timer, limits on defensive shifts and bigger bases are coming to major league baseball this season.
RELATED: Major League Baseball's new rules in the spotlight on Opening Day
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"Being a Cubs fan is the worst and the best thing that has ever happened to me you know," Jake Britton said. "We've had a lot of downtimes but very much a lot of positive times and as well there's a lot of optimism in the neighborhood. I can feel it too for sure so just very excited to be out here and get a new season underway."
Cubs president of business operations, Crane Kenney, said the first 10,000 fans will get an Opening Day pin.
Among the new features for fans at the ballpark is a Small Cheval int he stadium. Other food items for fans at Wrigley Field include the crispy chicken bao bun, Greek loaded fries, burger brat, crispy chicken torta, quesabirria and a souvenir beer bat.
Fans will also notice another new addition: the C.D. Peacock Trophy Room inside the Marquee Gate entrance, which will house the 2016 World Series trophy.
Cubs marketing senior VP Jen Martindale said Cubs fans will have about 50 different gameday promotions as well as special ticket offers, gate giveaways and ballpark celebrations.
Next, the Cubs will face this Milwaukee Brewers again on Saturday.