The shooting occurred in the southbound lanes of the Bishop Ford at 130th Street on Chicago's Far South Side.
Illinois State police responded to the shooting just before 2 a.m. A Chicago Fire Department spokesperson said a 45-year-old man was found shot in his vehicle and pronounced dead at the scene.
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Police shut down the southbound Bishop Ford ramp to eastbound 130th Street while they investigated the shooting. The ramp was back open by 5:48 a.m.
There are no reports of any other injuries from the shooting and no one is in custody. Details on the circumstances of the shooting were not immediately available.