The fire broke out in the 4500-block of South Hermitage Avenue sometime before 1 a.m. in the city's Back of the Yards neighborhood.
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CFD said two firefighters were taken for treatment in good condition, and another, who was stable, was taken to Stroger Hospital.
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Twenty seven people were displaced as a result of the blaze.
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It was not immediately clear what sparked the fire.
This is a developing story; check back with ABC7 Chicago for updates.