The fire started around 3 a.m. inside a two-story building in the 3800-block of South Kedzie Avenue.
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A man suffered from smoke inhalation and was transported to Stroger Hospital in critical condition , CFD said.
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Five residents have been displaced, CFD said. Warming buses were requested for residents.
CFD said later Monday that the probable cause of the fire was the careless use of candles.