The fire is in a multi-story building at 79th Street and Vincennes Avenue with a grocery on the first floor and residences on the upper floors.
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Flames could be seen shooting through the roof of the building and the fire was raised to a 3-11. The fire has extended to a neighboring building.
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Two firefighters have been injured fighting the blaze. Their injuries are not serious, CFD said. At around 9 a.m. the fire was struck.
The fire department said the building has been compromised and will need to be demolished. About 30 people have been displaced by the fire.