The fire broke out after 4 a.m. in the 1200-block of South Komensky Avenue and flames were seen coming through the roof of the home when firefighters arrived, CFD said.
One firefighter fell from the second floor, but a mattress in the home broke his fall, CFD said. He was evaluated at the scene.
A second firefighter was injured in his leg and transported to Mt. Sinai Hospital, but is expected to be OK.
No residents were hurt. The cause of the fire is under investigation.