The fire broke out in a 1 and 1/2 story home in the 6900-block of South Parnell Avenue at about 1:55 a.m., the Chicago Fire Department said.
Firefighters rescued a 36-year-old paraplegic man and carried him out in a blanket. He was transported to St. Bernard Hospital and suffered a minor burn to his abdomen, CFD said. He is expected to be okay.
No other injuries were reported. A family on the first floor has been displaced by the fire.
The cause of the fire is under investigation.