It happened just after 11 p.m. Thursday night near 87th Street and Cottage Grove in the Burnside neighborhood, according to law enforcement officials.
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Chicago police said a black Honda sedan crashed into a red Durango, causing the Durango to flip over onto its roof and hit a male pedestrian, who died at the scene.
No other injuries were reported.
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The Honda drove away, police said.
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No information on the victim was immediately available Friday morning.
The Chicago Police Major Accidents Unit is investigating.
This is a developing story; check back with ABC 7 Chicago for updates.