The crash occurred at about 11:44 p.m. on the I-290 exit ramp at Austin Avenue and police officers observed smoke coming from the driver's side of the car, police said.
Officers were able to get the 29-year-old male driver out of the vehicle. He was transported to Loyola Hospital in critical condition, police said.
Three other people, an 18-year-old man, a 28-year-old man and a 25-year-old woman, were each hospitalized in good condition, police said.