Police said they stopped a sedan in an alley in the 300-block of South Kilbourn Avenue after they saw someone not wearing a seatbelt.
As officers approached, police said someone fired a shot in their direction and an officer returned fire. No one was hit by the gunfire.
A male suspect was taken into custody after a short foot chase and a second suspect fled on foot and is not in custody, police said.
A weapon was recovered at the scene. Area Four detectives are investigating.