Police said the victims were sitting on the front porch of a home in the 8300-block of South Hermitage. A white car parked behind the home and three people got out, walked close to the house and started shooting at about 1:20 a.m.
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A 26-year-old man was shot in the chest and stomach and transported to Christ Hospital, where he was pronounced dead, police said. He has been identified to the Cook County Medical Examiner's Office as James McChristian.
Three people wounded in the shooting were transported to Christ Hospital. A 25-year-old woman was transported in stable condition, with wounds to the arm and stomach, a 23-year-old woman was transported in good condition with a leg wound and a 23-year-old man was transported in good condition with a wound to the shoulder, police said.
Activist Andrew Holmes said a child was a witness to the shooting.
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"One of the females did have a child with her and the Chicago Police Department has that child. Individual came through the gangway, fired multiple shots and took off northbound. They may have been celebrating birthday," Holmes said.
Labor Day Weekend is historically very violent in Chicago. Last year 13 people were killed, 52 wounded. The year before that 8 people were killed, 46 wounded.
Chicago police have deployed an extra 1,300 officers to try to prevent that violence this year.
Sun-Times Media Wire contributed to this report