There is a large police presence at a busy corner of Chicago's Southwest Side near Midway Airport in the aftermath.
A large area has been cordoned off at West 47th and South Cicero Avenue. Multiple crashed vehicles were apparent at the scene, one of them in the intersection.
Chicago fire officials said an off-duty Cook County deputy was shot multiple times while in traffic. He was taken to Mount Sinai Hospital in serious to critical condition.
Sources told ABC7 the off-duty sheriff's officer was not the intended target; he was struck by multiple bullets at the intersection when gunfire erupted between two vehicle. The shooting also resulted in multiple crashes.
The shooter's car then took off, the source said.
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Neighbors reported seeing a police helicopter overhead, and so there appears to be some type of search under way. Officers on foot were seen searching garbage cans and other areas behind a McDonald's.
Members of the Chicago Fire Department and Cook County Sheriff's Office are also on the scene.
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The incident happened within the 9 p.m. hour in the 4700 block of West 47th Street near the border of Archer Heights and Sleepy Hollow, and a bit north of Midway International Airport.
No further details have been released. Chicago police have not yet commented on the incident.