The 15-year-old was shot in the 2700-block of W. Pope John Paul II Blvd around 3:30 p.m., police said, before losing control of his vehicle and crashing a few blocks away on California Avenue near 42nd Street.
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Police said the gunshots were fired from a red-colored sedan that drove alongside the victim's vehicle.
The teen was transported to Mt. Sinai Hospital in good condition, police said. Police did not say if anyone in the other vehicle was injured.
No one is in custody. Area One detectives are investigating.