The victims were inside a car in the 1900-block of North Drake Avenue at about 2:30 a.m. when someone on the sidewalk fired shots and hit them.
A 37-year-old woman was shot in the back and arm and transported to Stroger Hospital in serious condition. A 52-year-old man was shot in the face, shoulder, arm and hand and was transported to Mount Sinai Hospital in fair condition.
A 6-year-old boy who was in the vehicle was not injured.
No one is in custody. Area Five detectives are investigating.