Police responded to a home in the 8000-block of South Stewart Avenue at about 5:04 a.m. and found the shooting victims.
A 29-year-old man was found dead on the living room floor, police said. Authorities have not released his identity.
A 20-year-old woman was shot in the leg and transported to St. Bernard Hospital in good condition. An 18-year-old man was also wounded and self-transported to Trinity Hospital. His condition is not known.
Further details on the shooting were not immediately available. Area Tw detectives are investigating.