Officers responded to the 7100-block of South Yates Boulevard and found the victims, police said.
A 16-year-old girl was shot and transported to the University of Chicago Medical Center in critical condition, where she later died police said.
A 32-year-old woman was shot and transported to the University of Chicago Medical Center in good condition.
Investigators said they were shot by two unidentified suspects who fled the scene on foot.
Area Three detectives are investigating and no one is in custody.
INTERACTIVE SAFETY TRACKER Track crime and safety in your neighborhood