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The victims were standing in an alley in the 8600-block of S. Damen Avenue in the Gresham neighborhood around 3:20 p.m. when an unknown vehicle drove by and someone inside began shooting at the group.
A 39-year-old man was shot in the left leg, a 24-year-old man was also shot in the left leg and foot, and a 42-year-old man and a fourth man of unknown age sustained multiple gunshot wounds to the body. All four were transported to Christ Hospital in varying conditions, according to police.
A fifth person was transported to Little Company of Mary Hospital, CPD said.
Police did not release a description of the vehicle.
Area Two Detectives are investigating.