A 39-year-old man was sitting in the driver's seat of a parked vehicle in the 2900-block of East 126th Street when police said someone opened fire just before 6 a.m.
Police said the married father of four was shot multiple times and pronounced dead at the scene. Authorities have not released his identity.
The victim's bullet-riddled car, a white Dodge Charger, could be seen parked outside a manufacturing business before it was towed from the scene.
Friends said the man had been a worker at the Ford assembly plant for over 10 years and have no idea why he was parked in another business' lot or why anyone would want to hurt him.
Investigators said they hope security cameras in the area will lead them to whoever is responsible for the shooting. Police said it is unclear if the attack was targeted.
Police have not yet released a motive for the crime. So far, no one is in custody.