The girl was inside a home in the 9800-block of South Throop Street at about 2:30 a.m. when police said two male suspects began firing into the residence.
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Police said the girl suffered a graze wound to the buttocks and was transported to Comer Children's Hospital in good condition.
No one is in custody. Area Two detectives are investigating.
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So far in 2022, more than 100 juveniles have been shot, 18 of them were killed.