The girl was inside a home in the 9800-block of South Throop Street at about 2:30 a.m. when police said two male suspects began firing into the residence.
Police said the girl suffered a graze wound to the buttocks and was transported to Comer Children's Hospital in good condition.
No one is in custody. Area Two detectives are investigating.
So far in 2022, more than 100 juveniles have been shot, 18 of them were killed.