Both women were shot in the lower body and transported themselves to the hospital. Their conditions were immediately unknown.
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The shooting occurred at about 8 p.m. in the 2700-block of West Ogden near the hospital's ER department in the city's Douglas Park neighborhood.
The hospital has been placed on lockdown Saturday night as a precautionary measure, prohibiting visitors from going inside.
No one was in custody. The offender was in a dark-colored sedan that pulled up and started firing shots.
Family members said this could be related to a shooting that occurred this afternoon in the 3700-block of West Roosevelt. In that shooting, a 25-year-old man was shot and taken to Mount Sinai Hospital in critical condition. Family said the man was riding a bicycle near a gas station when someone fired multiple shots at him.
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The two female victims are family members of the man shot on Roosevelt.
No one was in custody Saturday night in the Roosevelt shooting.
Police are investigating.
2 women shot outside Mount Sinai Hospital