Illinois State Police and Chicago fire officials said a 26-year-old man was shot multiple times about 8:15 p.m. while driving in Chicago's Lawndale neighborhood, near Lexington Street and Sacramento Boulevard.
Chicago police said someone in a silver Nissan Maxima fired the shots, then drove west on the Eisenhower Expressway.
The victim also drove onto the outbound Eisenhower Expressway, where emergency crews responded.
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He was taken to Stroger Hospital in serious condition but was later upgraded to fair. Two children, a 1-year-old boy and a 6-year-old boy, in the car were also taken to Stroger to get checked out, as there was shattered glass in the vehicle.
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Illinois State Police said the outbound Eisenhower was closed between California Avenue and Pulaski Road during the investigation.
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No one was in custody Friday morning, and Area Four Chicago police detectives are investigating.