According to police, around 3:20 a.m. an off-duty officer was getting into his personal vehicle when he was approached by two unknown men near the 3900-block of S. Artesian Avenue.
One of the suspects displayed a handgun and fired shots at the officer, police said.
Police said the officer did return fire, however it is unclear if the offenders were struck.
The officer was struck in the right leg and transported to Mt. Sinai Hospital, police said. He is in fair condition.
Neighbor Armando Leandro heard several loud gunshots which woke his family up.
"My mom saw someone when she looked outside she saw someone ran but she couldn't tell who it was because it was super fast and there was a car that ran and took off," he said.
No one is in custody.
Area One detectives are still investigating.
The officer involved will be placed on routine administrative duties for 30 days, police said.
On Monday, another Chicago police officer was shot in Austin.
According to police, officers responded around 12:20 a.m. for reports of shots fired during a domestic dispute in the 500-block of North Leamington Avenue.
The suspect fired a shot at an officer standing at the top of the stairs, hitting him in the shoulder, police said.
The officer's protective vest stopped the bullet and the officer returned fire, but no one was hit.
That suspect now faces a felony charge of attempted murder and a felony charge of unlawful use of a weapon by a felon, Chicago police said.