The woman was sitting in her vehicle in the 10200-block of South Michigan Avenue about 3 p.m. when two people approached her and pulled out a gun, Chicago police said.
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The woman, who had a valid concealed-carry license and FOID card, also pulled out a gun and fired shots.
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No injuries were reported, police said.
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The suspects fled in an unknown direction, and no one is custody.
Area Two detectives are investigating.