Police said the shooting happened in the Greater Grand Crossing neighborhood near East 68th Street and South State Street at about 3:20 p.m.
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Two men, 30 and 22 years old, were heading northbound on State Street in a blue sedan when a silver vehicle pulled up, and two people inside fired shots, police said. The suspects then fled northbound on State Street.
Police said the 30-year-old was shot in his body and head and the 22-year-old was shot in his neck and head. Both victims were transported in critical condition to the University of Chicago Medical Center, where they were pronounced dead.
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No one is in custody and Area One detectives are investigating.
Police did not immediately provide further information about the shooting.
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