Police said it happened near West 93rd Street and South Racine Avenue in the Brainerd neighborhood just after 7 p.m.
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Three teen boys and a man were inside a second-floor home when an argument ensued, police said. That's when a 16-year-old boy took out a gun and fired shots.
A 15-year-old boy, shot in his abdomen and left arm, was transported to Comer Children's hospital in critical condition.
Another 15-year-old boy, shot in his right shoulder, was taken to the same hospital in fair condition.
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A 21-year-old man, who suffered gunshot wounds to his right shoulder and buttocks and a graze wound to his forehead, was transported to Christ Hospital in critical condition.
The 16-year-old who fired the gun was shot in his right hand and abdomen, police said. He was taken to Comer Children's Hospital in fair condition. It was not immediately clear whether someone else fired shots.
Area Two detectives are investigating the circumstances surrounding the shooting. Police did not immediately provide further information.
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