Police said the victims were in the car in the 1100-block of West 63rd Street at about 2:36 a.m. when three male suspects got out of a gray Hyundai sedan and fired shots.
One man was transported to the University of Chicago Medical Center with wounds to the chest and was pronounced dead, police said.
A 35-year-old man was transported to the University of Chicago Medical Center in fair condition with a wound to the right leg, police said.
No one is in custody and Area One detectives are investigating.