The crash happened in the 12700 block of South Torrence Avenue.
Seven adults were initially reported to be in critical condition, CFD said. Three children ages nine, five and two were all taken to Comer Children's Hospital in good condition, according to Chicago police.
According to Chicago police, four vehicles were involved in the crash. A man driving a sedan northbound on Torrence Avenue went into the southbound lanes and crashed head on into an SUV. Two other vehicles swerved to avoid the collision and crashed, police said.
The man in the sedan died at the Advocate Christ Hospital, according to police.
So far no citations have been issued. Major Accidents are investigating.
People passing by told ABC7 that the area is known for drag racing. Chicago police have not said whether drag racing was involved.