It all unfolded around a popular business district in the Loop and even though this stabbing happened late at night, it still adds to a recent trend of crime around this area that has commuters concerned.
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"Frustration because I work here and sometimes I do get a little freaked out," said Heather Heagy, who works in the area.
Officers responded to the 100-block of West Van Buren Street at about 10:54 p.m. and found a 41-year-old man with multiple stab wounds, police said.
Police say he was approached by someone or a group of people and was stabbed multiple times. He then walked about a block away for help before collapsing near Van Buren and Financial Place.
The victim was transported to Northwestern Memorial Hospital, where he was pronounced dead, police said. Authorities have not released his identity.
Police released surveillance images of two men suspected in the stabbing.
No one is in custody and Area Three detectives are investigating.
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No bond for suspect in River North road rage stabbing near Mag Mile
"This area's kind of quiet with the rise in violence around the city I'm a little more -- not apprehensive but aware of my surroundings, but to have it happen right here was really shocking," said Daniel Concannon, who also works in the area.
According to Chicago Police Department data, the seven homicides that have happened so far this year in the Loop account for just 1% of homicides that have happened across the entire city this year. But the recent trend is still worrying many people who live and work here.
"I know sometimes I come into the office around 6:30 -7 in the morning and it can be a little all by yourself so I'd like to see more patrols around here," Concannon said.
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The incident is the second deadly stabbing downtown in two weeks.
Just two weeks ago, on August 23, Jeremy Walker was stabbed in the neck during a road rage attack downtown.
Walker managed to drive and get help and later died at the hospital. A man has been charged in the case.
"You should be alert always," said resident Tony Tungia. "If you see someone interested in you, you should be careful."