CPD said the incident began around 7:45 p.m. in the 100-block of West Ohio Street when two people got into an altercation. That's when the victim was stabbed in the neck, according to police.
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The victim found police officers about five blocks east in the 600-block of North Michigan Avenue, who then took him to Northwestern Memorial Hospital where he was pronounced dead.
No further details about the victim have been released. Police have not released any description of a suspect.
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Chicago police do not have a suspect in custody and an investigation is ongoing.
One woman who lives in River North said it's crimes like this and overall gun violence in the city that have become part of the reason she's leaving Chicago.
"You have to be on edge when you're walking, it's any time of day, and as a woman too, you're accosted by homeless people, you're accosted by unsurly people," Vesna Arsic said. "And I can outrun people because I'm an athlete, but I can't outrun bullets."