Chopper 7 was over the scene of the crash near the Interstate 55 interchange. The crash happened in drive's the southbound lanes.
It appears that at least two vehicles were involved in the collision. The conditions of those injured were not immediately known.
The crash is also impacting the Wednesday afternoon commute on the South Side.
Some lanes of traffic are getting by, but it's still creating some headaches for drivers there.
Further information was not immediately available.