More than 24,000 fans were in the stands Monday night, making it the largest attended event in Illinois in more than a year.
"It's definitely a sign that we're headed the right direction," Samuel Cundari said. "Both of us have been vaccinated, so it's good to get back out here and kind of return to a sense of normalcy."
The White Sox went as far as to open up vaccination sites at Guaranteed Rate Field, even offering fans a $25 gift card for anyone who gets a shot before the start of the game.
Over the weekend, the Sox featured vaccination-only sections for fans who presented vaccination cards or other proof along with a photo ID.
The Chicago Cubs also plan to open up games to more fans Friday by hosting 60% of Wrigley Field's capacity.