That accident closed down all southbound lanes of I-94 near 29th Street for several hours. The lanes have since reopened.
One person, the driver of the sedan involved in the crash, has been hospitalized with life-threatening injuries.
Debris was spread across multiple lanes of the expressway.
Police have not said what caused the crash, but weather likely was a factor.
The roads had been slick since Saturday night as a wintry mix of snow and rain came down for hours. The roads remained slippery later Sunday morning.