Safety measures will be in place to protect guests.
Masks will be required when social distancing isn't possible, and the only indoor spaces that will be open are restrooms.
RELATED: Chicago COVID restrictions: Field Museum, Art Institute, Shedd Aquarium set to reopen as metrics improve
The zoo will operate at 25% capacity, and reservations must be made online.
Chicago's Lincoln Park zoo also announced it would reopen March 5 with similar restrictions.
Chicago's Shedd Aquarium has already reopened and is even offering several free days coming up.
Chicago's Field Museum and Art Institute have also reopened, as COVID-19 metrics improve across the state.