It happened Sunday around 11:30 a.m.
According to police, the woman bumped into a person and exchanged words about social distancing.
That's when police say the woman yelled, '(expletive), I don't have the virus.' She then allegedly pulled down her mask and spit on the person before fleeing.
RELATED: Man charged with punching nurse who coughed on CTA bus
The victim was wearing a protective mask and glasses at the time.
A store employee told police the woman had an altercation the day before and spit on him after a dispute over how she wanted to pay for items.
The woman is described as 30 to 35 years old and 5-foot-6-inches tall, with a thin build and long reddish-brown hair. She was last seen wearing a three-quarter-length black jacket, dark pants and a red bandana around her neck.
Anyone with any information is asked to call police at 215-686-TIPS.