Illinois State Police said the two-vehicle crash caused the truck to jump the median wall and land near the CTA tracks below.
ISP confirms at least one person inside the pick-up was transported to the University of Chicago hospital where they were pronounced dead.
It's not clear if anyone else was inside the truck or if anyone else was injured.
Alcohol is suspected to be involved, police said.
The accident shutdown the northbound express lanes from 47th street to the Chinatown feeder ramp for hours.
All lanes have reopened, according to ISP.
No charges have yet been filed.