Police were notified of the crash at 1:24 a.m. of the crash in the inbound lanes near 18th Street.
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The Illinois Department of Transportation said it started with two separate crashes involving semi-trucks.
IDOT said one semi-truck hit barrels near Canalport and there was a fuel spill, which created slick conditions leading to a chain-reaction crash.
Drivers trying to pass the crash lost control of their vehicles, leading to a chain-reaction crash.
"I was driving and it was so slick suddenly I couldn't stop and cars were crashing into each other in front of me and so I turned and there was a space between two cars," crash victim Arthur Whitehouse said. "I tried to make it through and clipped on the rear end of this truck."
"I was coming on that S curve everybody lost control... It was slippery. Even when I got out of the car I thought it was gonna be ice, I didn't know what happened but we were all losing control at the same time," David said.
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Emergency workers even having a hard time walking on the expressway to help clean up because the ground was so slick.
Two women, ages 18 and 44, were transported to Northwestern Memorial Hospital in serious condition, police said.
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A 44-year-old man was transported in fair-to-serious condition to Stroger Hospital, police said.
A 42-year-old man, 21-year-old woman and 16-year-old girl were transported to Stroger Hospital in fair-to-serious condition, police said.
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A 44-year-old man was transported to Insight Hospital in good condition, police said.
At least 10 others refused transport, police said.
The inbound lanes of the Dan Ryan Expressway were closed at Canalport and have since reopened. IDOT said needed nine tons of sand to clean up the fuel spill.