The shooting occurred at about 4:14 a.m. near Marquette Road. A 27-year-old man was shot multiple times in the legs and was transported to a hospital in serious condition.
Two others were injured by debris, authorities said. They are expected to be OK.
Illinois State Police shut down the inbound lanes from 79th Street to Marquette Road at about 4:30 a.m. All entrance ramps from 79th Street to Marquette Road are closed as well.
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Shortly before 7 a.m., police reopened the inbound lanes of the Dan Ryan. Lanes were initially closed between 87th Street and Marquette Road.
Anyone with information is asked to contact Illinois State Police at 847-294-4400.