FBI Chicago led the multi-year investigation, which shut down two separate drug trafficking operations.
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Some of the defendants allegedly supplied drugs to customers in other states, including Wisconsin, Minnesota and Ohio.
Law enforcement officials seized nearly $400,000 in cash, cocaine, heroin, marijuana, Bentley and Mercedes-Benz automobiles and a custom-built motorcycle.
Most of the defendants were arrested Friday or early this week, and have begun making initial appearances in U.S. District Court in Chicago.
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