The crash happened around 3:30 p.m., on DuSable Lake Shore Drive near the Bryn Mawr exit and involved multiple vehicles, according to the Chicago Fire Department.
Emergency responders were on scene in both the northbound and southbound lanes as it appeared at least one vehicle involved in the crash was in both sets of lanes. A third vehicle appeared to be off in a grassy area.
Fire officials said two injured people were taken to Illinois Masonic Medical Center and a third person was taken to St. Francis Hospital. Their conditions were not immediately known.
No details have been released on the cause of the crash, or how many people are involved.
Two of the four lanes of both south and northbound DuSable Lake Shore Drive are blocked for the investigation; drivers should look for alternate routes and be prepared for traffic delays.