State police said the shooting was reported on eastbound I-290 near California Avenue around 2:19 p.m. Troopers shut down all inbound lanes for the investigation around 3:30 p.m. All lanes were reopened around 5:30 p.m.
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Two people with gunshot wounds drove to a local hospital, police said. No information was immediately available on their conditions.
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Two people were killed and one was injured in a shooting and single-car crash on the Eisenhower Expressway Sunday.