The incident happened at a store on the 7400-block of North Western Avenue at about 9:46 p.m.
The two suspects entered the store an announced a robbery. The employee fired a weapon and hit both suspects, who fled the scene.
The men were taken into custody a short time later. One was hospitalized with a wound to the shoulder and the other wounded in the right forearm.
The store employee has a valid concealed carry license. He was not seriously hurt.