The victim was identified as Kristi L. Swopes, according to the Cook County Medical Examiner's Office.
Swopes was traveling southbound when she was thrown from her vehicle after hitting another vehicle at about 4:25 a.m. near 159th Street in Calumet City, police said.
She was then hit by a third car. Police said a semi-truck may also be involved.
All outbound lanes were closed briefly after the crash.