Firefighters put out the flames of the fire in a single-family home near West 101st and South LaSalle streets at around 11:30 p.m., fire officials said.
Two adults were transported to Roseland Community Hospital, one in fair-to-serious condition and the other in good condition, fire officials said. One of them is wheelchair-bound.
The injured firefighter was transported to Mercy Hospital in good condition.
Fire officials said the fire was contained to the home and was out within 30 minutes.