Investigators said Lake County sheriff's deputies tried to stop the car for speeding in downtown Gary. The driver then led police on a high-speed chase that ultimately ended in a fatal crash on I-80.
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Investigators said the driver was speeding and weaving in between lanes when he lost control, hit a semi, spun across all lanes and collided with another tractor trailer around 11:32 a.m. in the westbound lanes near mile marker 5.7.
The impact of the crash ejected a 20-year-old woman from south suburban Matteson who was riding in the front passenger seat, investigators said.
She and an infant in a car seat were both pronounced dead on the scene, according to investigators. Their identities have not yet been released.
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The male driver was hospitalized with head injuries. Authorities said multiple charges against him are pending.
Investigators also said the driver was in illegal possession of a gun and was also arrested in November after a police pursuit.
The Indiana State Police Crash Reconstruction Unit is investigating the crash.