At least half a dozen secret service police were seen entering a home near Western Avenue and Geneva Street.
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Secret Service agents were also seen going in and out of the residence.
Glen Ellyn police initially said the area is closed due to police activity and confirmed the secret service was conducting an investigation. Police said that there is no current danger to the public.
It was not immediately known what the nature of the investigation was.
"I woke up and there was a ton of cop cars, SWAT team," neighbor Grete Muscatello said. "I had no idea what was going on."
Muscatello lives across the street from the home where Secret Service police spent hours sifting through belongings. She said she never expected to have a group of federal police show up at one of her neighbors' homes
"I was expecting caution tape, I was expecting perhaps an ambulance," Muscatello said. "I've never seen anything out of him that would indicate a SWAT team or anything serious in nature."
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In all, about 50 boxes and bags were taken from the house, likely filling a U-Haul truck that was driven off by Secret Service police around 1:30 p.m.
Neighbors said the family that lives in the home has been there for more than seven years.
"Secret Service... I find that very unusual," neighbor Joanne Travers said.
In addition to protecting dignitaries, the Secret Service is also charged with investigating financial crimes, including counterfeiting, credit card fraud and other financial crimes.