The shooting happened just after 9 p.m. Saturday on Michael Todd Terrace just west of Milwaukee Avenue.
Officers found two people who had been shot multiple times. One victim was pronounced dead on the scene and another was taken to a hospital, where he was later pronounced dead.
The victims have been identified as 16-year-old Jose Guzman and 19-year-old Carlos Guzman.
No one is in custody. Police asked anyone with information to contact them at 708-865-4896.